Prognostic significance of ASXL1 mutations in acute myeloid leukemia: A systematic review and meta-analysis

Prognostic significance of ASXL1 mutations in acute myeloid leukemia: A systematic review and meta-analysis

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Background: Although genetic mutations in additional sex-combs-like 1 (ASXL1) are prevalent in acute myeloid leukemia (AML), their exact impact on the AML prognosis remains uncertain.Hence, the present article was carried out to explore the prognostic importance 4 Piece Entertainment Unit with Fireplace of ASXL1 mutations in AML.Methods: We thoroughly searched electronic scientific databases to find eligible papers.Twenty-seven studies with an overall number of 8,953 participants were selected for the current systematic review.

The hazard ratio (HR) and 95% confidence interval (CI) for overall survival (OS), event-free survival (EFS), and relapse-free survival (RFS) were extracted from all studies with multivariate or univariate analysis.Pooled HRs and p-values were also calculated as a part of our work.Results: The pooled HR for OS in multivariable analysis indicated that ASXL1 significantly diminished survival in AML patients (pooled HR: 1.67; 95% CI: 1.

342-2.091).Conclusions: ASXL1 mutations may confer a poor prognosis in AML.Hence, they may be regarded as potential prognostic factors.

However, more detailed studies with different ASXL1 mutations are suggested to Zanussi ZGGN755K Built In 74cm 5 Burners Gas Hob Black LPG Convertible shed light on this issue.